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KMID : 1103920070130010009
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Korean Journal of Hepatology
2007 Volume.13 No. 1 p.9 ~ p.19
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Hypoxia in Hepatocellular Carcinoma
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Myung Sun-Jung
Yoon Jung-Hwan
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Abstract
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Hepatocellular carcinoma (HCC) is characterized by hypervascularity, indicating that angiogenesis plays a vital role in HCC growth and progression. A number of anti-angiogenic therapies are being utilized in clinical trials in patients with HCC. However, the therapeutic efficacy of anti-angiogenic monotherapy is still insufficient. While inhibition of angiogenesis results in tumor hypoxia and cell death, this inhibition may also activate hypoxia-induced cell signals that may promote HCC progression. Therefore, an understanding of these signals may be essential in designing efficient anti-angiogenic therapies. This review summarizes the role of hypoxia-induced signals in HCC.
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KEYWORD
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Carcinoma, hepatocellular, Angiogenesis inducing agent, Angiogenesis inhibitors, Hypoxia
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